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Kazusamycin B (Hydroxyleptomycin A, Antibiotic CL 1957E, Antibiotic PD 124895, 3. PD 124,895 )
Kazusamycin B (Hydroxyleptomycin A, Antibiotic CL 1957E, Antibiotic PD 124895, 3. PD
124,895 )
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| Kazusamycin B is a minor component of the leptomycin complex produced by some Streptomyces sp. It is an hydroxylated analogue of Leptomycin A, a nuclear export inhibitor. Kazusamycin B displays potent antitumour activity against L1210 and human colon adenocarcinoma and in vivo activity against P388 lymphocytic leukemia in mice. Kazusamycin B also possesses strong antibacterial and antifungal activity. | | | Catalog # | K0108-85A | | Purity | >95% by HPLC | | Solubility | Soluble in ethanol or methanol. Ethanol recommended. Unstable in DMSO. | | Related to | Anguinomycin A, Leptomycin A, Leptomycin B, Kazusamycin A | | CAS Number | 107140-30-7 | | Molecular Formula | C32H46O7 | | Molecular Weight | 542.7 | | Source | Streptomyces sp. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Hydroxyleptomycin A, Antibiotic CL 1957E, Antibiotic PD 124895, 3. PD 124,895 |
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