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You are here:Home » Antibodies » Abs to Keratin, Cytokeratin » Anti -Keratin 8 (Keratin Type II Cytoskeletal 8, Keratin-8, K8, KRT8, CARD2, Cytokeratin-8, CK8, CK-8, CYK8, K2C8, KO, Type-II Keratin Kb8)

Anti -Keratin 8 (Keratin Type II Cytoskeletal 8, Keratin-8, K8, KRT8, CARD2,
Cytokeratin-8, CK8, CK-8, CYK8, K2C8, KO, Type-II Keratin Kb8)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
Among the cytoplasmic intermediate filaments (IF) proteins, keratins make up the largest family and are expressed specifically in epithelial cells in a cell-specific manner. Keratins include more than 20 unique gene products (termed K1-K20) that are divided into type I (K9-K20) and type II (K1-K8). Most epithelial cells express at least one type I and one type II keratin as their predominant IF protein complement in an epithelial cell-specific manner. Keratin18 is a type-I keratin that is found in a variety of simple epithelial tissues. Keratin 8 and 18 (K8/18) phosphorylation plays a significant and site-specific role in regulating keratin filament organization, association with binding proteins, and modulation of cell cycle progression. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. The gene for human Keratin18 maps to 12q13 region of chromosome. It is expressed in colon, placenta, liver and very weakly in exocervix.
Catalog #K0199-09D
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochestry (paraffin): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic non-phosphopeptide corresponding to human Keratin 8 around the phosphorylation site of serine 73 (L-L-SP-P-L).
SpecificityRecognizes human Keratin 8.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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