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You are here:Home » Antibodies » Abs to Keratin, Cytokeratin » Anti -Keratin 17

Anti -Keratin 17

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant IH IF
The type I keratin 17 (K17) shows a peculiar localization in human epithelial appendages including hair follicles, which undergo a growth cycle throughout adult life. Additionally K17 is induced, along with K6 and K16, early after acute injury to human skin. Predominant expression of K17 and the frequent expression of K8 and K19, with little K6/K16 and K1/K10 expression are the characteristic features of basal cell carcinomas (BCC). This expresssion indicates BCC is differentiated towards undifferentiated follicular epithelia, most probably hair bulge cells.
Catalog #K0199-20
ApplicationsSuitable for use in Immunofluorescence and Immunohistochemistry. Other applications have not been tested.
Recommended DilutionImmunohistochemistry (frozen & formalin/paraffin): 1:40-1:80 for 30 min at RT. Note: Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 min., followed by cooling at RT for 20 min.
Optimal dilutions to be determined by the researcher.
Positive ControlSquamous cell carcinoma or skin
Cellular LocalizationCytoplasmic
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C or colder. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2b,k
Clone No0.N.362
HostMouse
SourceRat
ConcentrationNot determined
FormSupplied as a liquid, concentrated tissue culture supernatant, 15mM sodium azide.
PurityTissue culture supernatant
ImmunogenKeratin preparation from rat enterocytes.
SpecificityRecognizes keratin 17 at 46kD. Species Crossreactivity: Human and Rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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