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You are here:Home » Antibodies » Abs to Keratin, Cytokeratin » Anti -Keratin-18, ID (Keratin, Type I Cytoskeletal 18, Cytokeratin-18, CK-18, Dorsal Aorta Proneprin Kinesin-1, DreK18, Keratin-18, K18, dapk1, krt18)

Anti -Keratin-18, ID (Keratin, Type I Cytoskeletal 18, Cytokeratin-18, CK-18, Dorsal Aorta
Proneprin Kinesin-1, DreK18, Keratin-18, K18, dapk1, krt18)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Intermediate filaments (IFs), together with actin microfilaments and tubulin microtubules, comprise the three major cytoskeletal networks that are found in most eukaryotic cells. Keratins, which are the largest IF protein subgroup, can be divided into the acidic type I (K9-K20) and basic type II (K1-K8) keratins. Typically, epithelial cells express at least one of each type, and the proteins exist in the cells as noncovalent obligate heteropolymers. Keratin networks are highly dynamic and reorganized during cell differentiation, mitosis and apoptosis, and also play important cytoprotective and structural support roles for the cell. During apoptosis, the epithelial keratins 18 and 19 undergo caspase- mediated proteolysis, leading to the disassembly of the nuclear envelope and cytoplasmic IF networks.
Catalog #K0199-22V
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:5000-1:20,000
Western Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Control Peptide K0199-22Y
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceZebrafish
ConcentrationNot determined
FormSupplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the intermediate region of zebrafish Keratin-18.
SpecificityRecognizes zebrafish Keratin-18.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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