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You are here:Home » Antibodies » Abs to Keratin, Cytokeratin » Anti -Keratin 19 (Asp237) (Keratin, Type I Cytoskeletal 19, Cytokeratin-19, CK-19, Keratin-19, K19)

Anti -Keratin 19 (Asp237) (Keratin, Type I Cytoskeletal 19, Cytokeratin-19, CK-19,
Keratin-19, K19)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B
Intermediate filaments (IFs), together with actin microfilaments and tubulin microtubules, comprise the three major cytoskeletal networks that are found in most eukaryotic cells. Keratins, which are the largest IF protein subgroup, can be divided into the acidic type I (K9- K20) and basic type II (K1-K8) keratins. Typically, epithelial cells express at least one of each type, and the proteins exist in the cells as noncovalent obligate heteropolymers. Keratin networks are highly dynamic and reorganized during cell differentiation, mitosis and apoptosis, and also play important cytoprotective and structural support roles for the cell During apoptosis, the epithelial keratins 18 and 19 undergo caspase-mediated proteolysis, leading to the disassembly of the nuclear envelope and cytoplasmic IF networks. K18 and K19 undergo caspase-cleavage at the conserved Asp237 in their rod domains. In contrast to other type I keratins, K18 is unique in that it includes another caspase-cleavage site at Asp396 of the carboxy-terminal domain.
Catalog #K0199-24T
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-1:2500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid, 0.05% sodium azide.
PuritySerum
ImmunogenSynthetic peptide corresponding to an internal sequence surrounding aa237 (QVSVEVD) of human keratin-19.
SpecificityRecognizes human keratin-19.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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