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You are here:Home » Growth Factors, Cytokines » Growth Factors-KGF » Keratinocyte Growth Factor-1, Recombinant Human (KGF-1, Fibroblast Growth Factor 7, FGF-7)

Keratinocyte Growth Factor-1, Recombinant Human (KGF-1, Fibroblast Growth Factor 7, FGF-7)

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Specifications

Keratinocyte Growth Factor-1 (KGF-1/FGF-7) is one of 23 known members of the FGF family. All FGFs have two conserved cysteine residues and share 30-50% sequence identity at the amino acid level. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of variety of tissues, by promoting cellular proliferation and differentiation. KGF-1/FG-7 is a mitogen factor specific for epithelial cells and keratinocytes and signals through FGFR 2b. KGF-1/FGF-7 plays a role in kidney and lung development, angiogenesis, and wound healing.
Catalog #K0201-15B
Amino Acid SequenceMCNDMTPEQMATNVNCSSPERHTRSYDYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEMKNNYNIMEIRTVAVGIVAIKGVESEFYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHNGGEMFVALNQK GIPVRGKKTK KEQKTAHFLPMAIT
Biological ActivityThe biological activity was determined by the does-dependent stimulation of thymidine uptake by BaF3 cells expressing KGF receptors yielding an ED50 <10ng/ml, corresponding to a specific activity of 1x10e5 units/mg.
Endotoxin 1EU/ug as determined by LAL method.
Storage and StabilityAliquot to avoid repeated freezing and thawing and freeze at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months.
Storage and StabilityLyophilized powder may be stored at -20°C. Reconstituted product is stable for up to one week at 4°C. For maximal stability, apportion reconstituted material into working aliquots and store at -20°C to -70°C. Avoid freeze-thaw cycles. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~19.0 kD
SourceEscherichia coli
Purity96% by SDS-PAGE and HPLC analyses.
FormSupplied as a lyophilized powder in PBS, pH 8.0. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1mg/ml.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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