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3-Keto-N-aminoethyl-N’-aminocaproyldihydrocinnamoyl Cyclopamine (KAAD-Cyclopamine)
3-Keto-N-aminoethyl-N’-aminocaproyldihydrocinnamoyl Cyclopamine (KAAD-Cyclopamine)
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| Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and sonic hedgehog intracellular signaling. The KAAD derivative has shown 10-20 fold higher potency than cyclopamine in inhibition of beta-Galactosidase expression in Ptch(-/-) cells. | | | Catalog # | K0292 | | Solubility | As reported | | Melting Point | As reported | | Atmosphere | Inert gas | | Method for Determining Identity | Proton NMR (CD30D) Spectroscopic and Mass Spectrometric Analysis | | TLC Conditions | As reported | | Storage and Stability | May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. | | Light, temperature and moisture sensitive. Solutions are not stable. | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Toxicity and Hazards | All products should be handled by qualified personnel only, trained in laboratory procedures. | | CAS Number | 306387-90-6 | | Molecular Formula | C44H63N3O4 | | Molecular Weight | 697.99 | | Source | Synthetic | | Purity | ~90% | | Form | As reported | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | KAAD-Cyclopamine |
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