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You are here:Home » Biochemicals » Biochem-Steroids » 3-Keto-N-aminoethyl-Ní-aminocaproyldihydrocinnamoyl Cyclopamine (KAAD-Cyclopamine)

3-Keto-N-aminoethyl-Ní-aminocaproyldihydrocinnamoyl Cyclopamine (KAAD-Cyclopamine)

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Specifications

Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and sonic hedgehog intracellular signaling. The KAAD derivative has shown 10-20 fold higher potency than cyclopamine in inhibition of beta-Galactosidase expression in Ptch(-/-) cells.
Catalog #K0292
SolubilityAs reported
Melting PointAs reported
AtmosphereInert gas
Method for Determining Identity Proton NMR (CD30D) Spectroscopic and Mass Spectrometric Analysis
TLC ConditionsAs reported
Storage and StabilityMay be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Light, temperature and moisture sensitive. Solutions are not stable.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and HazardsAll products should be handled by qualified personnel only, trained in laboratory procedures.
CAS Number306387-90-6
Molecular FormulaC44H63N3O4
Molecular Weight697.99
SourceSynthetic
Purity~90%
FormAs reported
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesKAAD-Cyclopamine


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