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Specifications

Kigamicin C was discovered by an anti-austerity strategy targeting cancer cells' tolerance to starvation. It selectively kills PANC-1 cells (a pancreatic cell line) at concentrations 100 times lower under nutrient starved conditions than in normal conditions. The mechanism of action is proposed to be via blocking of the activation of PKB/Akt caused by the withdrawal of nutrients. Active in vivo against a human pancreatic cancer xenograft model. Also inhibits the growth of Gram-positive bacteria including Staphylococcus aureus MRSA, but not active against Gram-negative bacteria.
Catalog #	K1765-25
Purity	>95% by HPLC
Solubility	Soluble in ethanol, methanol, DMF or DMSO.
CAS Number	680571-51-1
Molecular Formula	C41H47NO16
Molecular Weight	809.8
Source	Amycolatopsis sp.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.