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You are here:Home » Biochemicals » Biochem-Antibiotics » Kigamicin C

Kigamicin C

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Specifications

Kigamicin C was discovered by an anti-austerity strategy targeting cancer cells' tolerance to starvation. It selectively kills PANC-1 cells (a pancreatic cell line) at concentrations 100 times lower under nutrient starved conditions than in normal conditions. The mechanism of action is proposed to be via blocking of the activation of PKB/Akt caused by the withdrawal of nutrients. Active in vivo against a human pancreatic cancer xenograft model. Also inhibits the growth of Gram-positive bacteria including Staphylococcus aureus MRSA, but not active against Gram-negative bacteria.
Catalog #K1765-25
Purity >95% by HPLC
Solubility Soluble in ethanol, methanol, DMF or DMSO.
CAS Number680571-51-1
Molecular FormulaC41H47NO16
Molecular Weight809.8
SourceAmycolatopsis sp.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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