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You are here:Home » Antibodies » Abs to Motor Proteins » Anti -Kinesin 5A (KIF5A, Kinesin Heavy Chain Neuron Specific)

Anti -Kinesin 5A (KIF5A, Kinesin Heavy Chain Neuron Specific)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Kinesins are a superfamily of microtubule-associated motor proteins involved in a variety of cellular processes including membranous organelle transport and cell division. Kinesin has been found in a variety of organisms and cell types and is subject to spatial and temporal regulation. These proteins have a modular structure including a conserved motor domain of approximately 350 amino acids, which is responsible for microtubule binding and ATP hydrolysis. In addition to the motor domain, subfamily members share common domain organization, exhibit sequence similarity, motility properties, and cellular functions outside of the motor domain. There are currently three known Kinesin 5 family members denoted as A, B, and C. Kinesin 5A and kinesin 5C appear to be exclusively neuronal, whereas kinesin 5B appears to be ubiquitous in its expression.
Catalog #K1781-50
Cellular Localization Concentrated in the cell body of the neurons, particularly in the perinuclear region.
Positive Control Mouse neuronal cell extract.
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 1mg/ml BSA, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide: CGYEAEDQAKLFPLHQETAAS, corresponding to amino acids 1007-1027 of Mouse Kinesin 5A, this sequence is completely conserved in human.
SpecificityThis antibody is specific for kinesin 5A and does not detect other kinesin isotypes. Species Crossreactivity: Crossreacts with bovine, Human and Mouse. Expected to crossreact with Rat (95% identity with immunogen) due to sequence homology. Not yet tested in other species.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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