Anti -KLRK1 (Killer Cell Lectin-like Receptor Subfamily K Member 1, CD314, HGNC:18788,
D12S2489E, NK Cell Receptor D, NK Lectin-like Receptor, NKLLR, NKG2D Activating NK
Receptor, NKG2D Type II Integral Membrane Protein, NKR P2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
IP FC |
|
| CD314, also known as natural killer receptor G2 (NKG2D) and as killer cell lectin-like receptor subfamily K, member 1 (KLRK1). CD314 is a C-type lectin-like activating receptor which is expressed on most natural killer (NK) cells, CD8 T cells and gamma delta T cells. CD314 forms homodimers that signal through an associated DAP10 adaptor protein.Ligands of CD314 include MICA, MICB and UL16 binding protein (ULBP), which are inducibly expressed. Ligand binding to CD314 results in NK cell activation and potent costimulation of effector T cells. | | | Catalog # | K1893-28F1 | | Applications | Suitable for use in Flow Cytometry, Functional Assays, and Immunoprecipitation. Other applications not tested. | | Recommended Dilution | Flow Cytometry: 1:100-1:200; 10ul labels 10e6 cells in 100ul | | Optimal dilutions to be determined by the researcher. | | Hybridoma | p3 myeloma cells with spleen cells from RBF/DnJ mice. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2a | | Clone No | 10B1386 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4. No preservatives added. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | NKL cells. | | Specificity | Recognizes human CD314. Reported to inhibit T cell recognition of MICA (1, 3). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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