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You are here:Home » Antibodies » Antibodies-Dickkopf Proteins » Anti -Kremen2

Anti -Kremen2


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
The Wnt family of secreted glycoproteins mediate cell-cell interaction during cell growth and differentiation in both embryos and adults. (1,2) Canonical Wnt signaling by way of the b-catenin pathway is transduced by two receptor families, frizzled proteins and lipoprotein-receptor-related proteins 5 and 6 (LRP5/6) which binds Wnts and transmit their signal by stabilizing intracellular b-catenin.(3-6) Kremen1 and Kremen2 are high-affinity Dkk1 receptors that functionally cooperate with the secreted protein Dickkopf1 (Dkk1) to block Wnt/b-catenin signaling.(7) Kremen1 and Kremen2 are components of a membrane complex modulating canonical Wnt signaling through LRP6 in vertebrates.(7) Dkk1 has been shown to inhibit Wnt signaling by binding to and antagonizing LRP5/6 (8-10).
Catalog #K5002
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.1-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide, before the addition of glycerol to 40%.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide derived from the internal region of human, mouse and rat Kremen2 proteins.
SpecificityRecognizes human, mouse and rat Kremen2 proteins at ~51kD. No cross-reactivity with the related Kremen1 protein. Reactivity has been confirmed with myc-tagged mouse Kremen2-transfected 293T cell lysates. Species sequence homology: human and rat-100%.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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