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You are here:Home » Antibodies » Abs to GTPase, Rab, Ras, Rho Proteins » Anti -KSR (Kinase Suppressor of Ras, KSR1, BKSR1, dKsr, EK31, hb, Positive Ras Signaling Mediator Family Member, RSU2, Suppressor of Activated let 60 Ras SUR3, Suppressor of Ras1 31, SR31)

Anti -KSR (Kinase Suppressor of Ras, KSR1, BKSR1, dKsr, EK31, hb, Positive Ras Signaling
Mediator Family Member, RSU2, Suppressor of Activated let 60 Ras SUR3, Suppressor of Ras1
31, SR31)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit B IH IC
The Kinase Suppressor of Ras (KSR1) is a recently identified participant in the Ras signaling pathway. KSR is capable of uncoupling the MAP kinase activation from its target phosphorylation, and thus provide a novel mechanism for modulating the Ras-MAP kinase signaling pathway. The recently identified, B-KSR, is a related isoform. KSR is thought to phosphorylate and activate Raf-1, protecting against cytokine-mediated apoptosis. Recent studies suggest that KSR interacts with several components of the MAP kinase pathway, including Raf-1, MEK1/2 and ERK1/2. KSR seems to act as a scaffolding protein that coordinates the assembly of a membrane-localized, multiprotein MAP kinase complex, a vital step in Ras-mediated signal transduction.
Catalog #K6850-01A
ApplicationsSuitable for use in Western Blot, Immunocytochemistry, Immunohistochemistry (Paraffin).
Other applications not tested.
Recommended DilutionWestern Blot Analysis: 1:500-1:2000
Immunocytochemistry: 1:50
Immunohistochemistry (Paraffin): 1:100-250
Optimal dilutions to be determined by the researcher.
Positive Control293 cell lysate.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG
Clone No10F647
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, 50mM Tris-Glycine, pH 7.4, 0.15M NaCl, 0.01% sodium azide, 0.05% BSA, 40% glycerol.
ImmunogenSynthetic peptide corresponding to residues near the C-terminus of human KSR1.
SpecificityRecognizes human KSR1. Species crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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