Anti -KSR (Kinase Suppressor of Ras, KSR1, BKSR1, dKsr, EK31, hb, Positive Ras Signaling
Mediator Family Member, RSU2, Suppressor of Activated let 60 Ras SUR3, Suppressor of Ras1
31, SR31)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rabbit |
|
B IH IC |
|
| The Kinase Suppressor of Ras (KSR1) is a recently identified participant in the Ras signaling pathway. KSR is capable of uncoupling the MAP kinase activation from its target phosphorylation, and thus provide a novel mechanism for modulating the Ras-MAP kinase signaling pathway. The recently identified, B-KSR, is a related isoform. KSR is thought to phosphorylate and activate Raf-1, protecting against cytokine-mediated apoptosis. Recent studies suggest that KSR interacts with several components of the MAP kinase pathway, including Raf-1, MEK1/2 and ERK1/2. KSR seems to act as a scaffolding protein that coordinates the assembly of a membrane-localized, multiprotein MAP kinase complex, a vital step in Ras-mediated signal transduction. | | | Catalog # | K6850-01A | | Applications | Suitable for use in Western Blot, Immunocytochemistry, Immunohistochemistry (Paraffin). | | Other applications not tested. | | Recommended Dilution | Western Blot Analysis: 1:500-1:2000 | | Immunocytochemistry: 1:50 | | Immunohistochemistry (Paraffin): 1:100-250 | | Optimal dilutions to be determined by the researcher. | | Positive Control | 293 cell lysate. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG | | Clone No | 10F647 | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS, 50mM Tris-Glycine, pH 7.4, 0.15M NaCl, 0.01% sodium azide, 0.05% BSA, 40% glycerol. | | Immunogen | Synthetic peptide corresponding to residues near the C-terminus of human KSR1. | | Specificity | Recognizes human KSR1. Species crossreactivity: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -KSR (Kinase Suppressor of Ras, KSR1, BKSR1, dKsr, EK31, hb, Positive Ras Signaling Mediator Family Member, RSU2, Suppressor of Activated let 60 Ras SUR3, Suppressor of Ras1 31, SR31) |
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