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You are here:Home » Antibodies » Abs to DNA Replication, Repair » Anti -Ku70 (DNA Replication, Repair and Recombination Factor)

Anti -Ku70 (DNA Replication, Repair and Recombination Factor)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IP
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80kD. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq]
Catalog #K7965
ApplicationsSuitable for use in ELISA, Western Blot, Immunoprecipitation, Gel Supershift Assay and Immunohistochemistry Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 1:100. Requires antigen retrieval using heat treatment prior to staining of paraffin
Western Blot: 1:5000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in sodium azide
PurityNeat serum
ImmunogenPurified human 70kD Ku subunit.
SpecificityReactive with human Ku 70 protein. Weak crossreactivity with Ku80 may be evident under some conditions. Species crossreactivity: Mouse, rat, hamster, xenopus.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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