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You are here:Home » Antibodies » Antibodies-DNA Replication, Repair » Anti -Ku80 (DNA Replication, Repair and Recombination Factor)(BSA & Azide Free)

Anti -Ku80 (DNA Replication, Repair and Recombination Factor)(BSA & Azide Free)


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Clone Host Grade Applications
Monoclonal Mouse Highly Purified E B IP FC IF
The Ku antigen was first described as a nonhistone nuclear antigen producing a precipitin line with serum from a patient with scleroderma-polymyositis overlap syndrome (1). Although originally thought to be relatively specific for this unusual subset of autoimmune disease, autoantibodies to Ku are also found in some sera from patients with systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD), scleroderma, polymyositis, Grave’s disease, and primary pulmonary hypertension (2).
Catalog #K8000-10X
ApplicationsSuitable for use in ELISA, Flow Cytometry, Immunofluorescence, Immunoprecipitation and Western Blot. Other applications not tested.
Recommended DilutionsImmunoprecipitation (native, denatured): 2ug antibody/mg protein lysate using Protein G.
Western Blot: 0.5-1.0ug/ml
Optimal dilutions to be determined by the researcher.
Positive Control
HeLa, T47D or BT474 cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No0.N.377
FormSupplied as a liquid in PBS, pH 7.4. Also available with BSA and azide. See K8000-10.
PurityPurified by ammonium sulfate precipitation.
ImmunogenHuman B cell nuclei from plasmacytoid 2p68 cells.
Cellular LocalizationNuclear
SpecificityReconizes the p80 subunit of Ku at 80kD. The epitope maps to between residues 610-705. Species Reactivity: Human and Monkey. Does not react with bovine, Rabbit, Mouse or Rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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