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You are here:Home » Antibodies » Abs to Ion Channel » Anti -Kv1.5 (Kcna5, Voltage-gated, Delayed-rectifier Potassium Channel)

Anti -Kv1.5 (Kcna5, Voltage-gated, Delayed-rectifier Potassium Channel)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP IH
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potasssium ions may pass in accordance with their electrochemical gradient. May play a role in regulating the secretion of insulin in normal pancreatic islets.
Catalog #K9003-10
Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes-shaker, shaw, shab, and shal-have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome.
ApplicationsSuitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 1:200-1:400 (Rat brain membranes).
Immunohistochemistry: Rat brain sections
Note: Dilutions should be made using a carrier protein such as BSA (1-3%).
Optimal dilution determined by the researcher.
EpitopeHRETD HEEQA ALKEE QGIQR RESGL DTGGQ RKVSC SKASF HKTGG PLEST DSIRR GSCPL EKCHL KAKSN VDLRR SLYAL CLDTS RETDL
Control Antigen IncludedK9003-10A1
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 1% BSA, 5% sucrose, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenGST Fusion protein and a C-terminal portion (aa513-602) of mouse Kv1.5 (Accession # Q61762). Epitope: HRETD HEEQA ALKEE QGIQR RESGL DTGGQ RKVSC SKASF HKTGG PLEST DSIRR GSCPL EKCHL KAKSN VDLRR SLYAL CLDTS RETDL
SpecificityRecognizes mouse Kv1.5. Species Crossreactivity: Rat, equine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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