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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified IH IC FC IF Gel

Lactoferrin is an iron binding glycoprotein with an approximate molecular weight of 80kD. The protein has two iron binding domains each housing one Fe 3+ and the synergistic CO 3 2- ion. The crystal structure form of human lactoferrin at 2.2A resolution exhibits 5330 protein atoms, 2Fe2+, 2CO 32- and 98 carbohydrate atoms. Lactoferrin is absorbed from intestine by apical side of the membrane and localized to the nuclei. Intravenous infusion of lactoferrin is protective against lethal doses of E. coli and induce bacterimia by a mechanism that downregulates neutrophil TNF alfa secretion. Recombinant human lactoferrin (rhLF), expressed and extracted from rice seed, is being evaluated for use as a dietary supplement to treat iron deficiency and/or iron deficiency induced anemia. Lactoferrin has been shown to have a role in the immune system and in early development of the embryo. A specific receptor for lactoferrin binding has been implicated in the human fetal intestine. Early embryonic localization of lactoferrin by IHC has suggested its presence in various tissues including intestinal epitheliuem, kiney, and various regions of the brain.
Catalog #	L1021-79
Applications	Suitable for use in Immunocytochemistry, Flow Cytometry, Immunocytochemistry and Immunofluorescence. Other applications not tested.
Recommended Dilution	Immunocytochemistry, Immunocytochemistry, Flow Cytometry, Immunofluorescence: 1:50-1:200
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Human
Concentration	~1mg/ml
Form	Supplied as a liquid in sodium phosphate, pH 7.2, 1mg/ml BSA, 0.05% sodium azide. Labeled with FITC.
Purity	Purified by immunoaffinity chromatography.
Immunogen	Purified Lactoferrin from human colostrum..
Specificity	Recognizes human milk lactoferrin. Does not crossreact with other milk or serum proteins. Species crossreactivity: May crossreact with lactoferrin from other species.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.