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You are here:Home » Antibodies » Abs to Serum Proteins » Anti -Lactoferrin (HRP)

Anti -Lactoferrin (HRP)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
Lactoferrin is an iron binding glycoprotein with an approximate molecular weight of 80kD. The protein has two iron binding domains each housing one Fe 3+ and the synergistic CO 3 2- ion. The crystal structure form of human lactoferrin at 2.2A resolution exhibits 5330 protein atoms, 2Fe2+, 2CO 32- and 98 carbohydrate atoms. Lactoferrin is absorbed from intestine by apical side of the membrane and localized to the nuclei. Intravenous infusion of lactoferrin is protective against lethal doses of E. coli and induce bacterimia by a mechanism that downregulates neutrophil TNF alfa secretion. Recombinant human lactoferrin (rhLF), expressed and extracted from rice seed, is being evaluated for use as a dietary supplement to treat iron deficiency and/or iron deficiency induced anemia. Lactoferrin has been shown to have a role in the immune system and in early development of the embryo. A specific receptor for lactoferrin binding has been implicated in the human fetal intestine. Early embryonic localization of lactoferrin by IHC has suggested its presence in various tissues including intestinal epitheliuem, kiney, and various regions of the brain.
Catalog #L1021-80
ApplicationsSuitable for use in Immunohistochemistry (tissue sections), ELISA and Western Blot. Other applications not tested.
Recommended DilutionImmunohistochemistry: 1:500-1:5000
ELISA: 1:5000-1:100,000
Western Blot (chromogenic substrates): 1:,5000- 1:100,000
Western Blot (ECL substrates): 1:10,000-1:200,000
Optimal dilutions to be determined by researcher.
Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration0.8mg/ml
FormSupplied as a liquid, pH 7.6,15m/gml BSA (IgG and Protease free), 40% glycerol. Conjugated to horseradish peroxidase (HRP).
PurityPurified by immunoaffinity chromatography.
ImmunogenLactoferrin (HRP)
SpecificityReacts with the human milk lactoferrin. Does not crossreact with other milk or serum proteins. Species crossreactivity: May crossreact with lactoferrin from other species.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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