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L1021-81G Rabbit Anti-Lactoferrin (Lactotransferrin, LTF, LF)

Specifications
Clone Type
Polyclonal
Host
Rabbit
Source
Bovine
Isotype
IgG
Grade
Affinity Purified
Applications
E IP WB
Crossreactivity
Bo
Shipping Temp
Blue Ice
Storage Temp
-20°C

Lactoferrin is an approximately 80kD glycoprotein which was first isolated from milk and found in epithelia and most body fluids and secretions. Lactoferrin is secreted in plasma by neutrophils. Its plasma concentration represents a positive relation to the total pool of neutrophils and the rate of neutrophil turnover. In inflammation lactoferrin is released from secondary granules of neutrophilic leukocytes into the extracellular medium. Therefore the extracellular lactoferrin concentration can be used as an index for neutrophil activation. Lactoferrin is able to strongly bind to iron and considered to have antibacterial properties. Human lactoferrin binds to bacterial products through its highly positively charged N terminus and kills various bacteria most probably by inducing intracellular changes in these bacteria without affecting the membrane permeability. Lactoferrin also plays a role in signal transduction, immunomodulation and has antiadhesive, anticancer, antiviral activity.

Applications
Suitable for use in Western Blot, Immunoprecipitation and ELISA. Other applications not tested.
Recommended Dilutions
Western Blot: 1:10 Immunoprecipitation: 1:10 Optimal dilution to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Bovine Lactoferrin.
Form
Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Recognizes bovine Lactoferrin.
Conjugates
Pricing
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