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You are here:Home » Growth Factors, Cytokines » Growth Factors-LAG-1 » LAG-1 (Lymphocyte activation gene-1 protein, CCL4L1)

LAG-1 (Lymphocyte activation gene-1 protein, CCL4L1)

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Specifications

Lymphocyte activation gene-1 protein (LAG-1) ia a CC chemokine and is part of the MIP-1 beta family. LAG-1 is identical to MIP-beta (ACTII isotype) except for two amino acid substitutions; arginine for histidine at position 22 and serine for glycine at position 47 of the mature protein. Like MIP-1 beta, it shows in ammatory and chemokinetic properties. Lag-1 binds to both CCR5 and to CCR8. Studies have shown that LAG-1 plays an essential role in HIV suppressive factors. Recombinant Human LAG-1 is a 7.7kDa protein containing 69 amino acid residues.
Catalog #L1050
Stability The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted LAG-1 should be stored in working aliquots at -20°C.
Purity 98% by SDS-PAGE and HPLC analyses
Endotoxin 0.1ng/ug (1EU/ug)
Reconstitution We recommend a quick spin followed by reconstitution in water to a concentration of 0.11.0 mg/ml. This solution can then be diluted into other buffers and stored at 4°C for 1 week or stored at -20°C for future use.
Biological Activity Determined by its ability to chemoattract CCR5 transfected cells using a concentration of 0.110.0ng/ml
AA Sequence APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRSKQV CADPSESWVQ EYVYDLELN
Country of Origin USA
SourceE. coli
FormThe sterile ltered solution was lyophilized with no additives.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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