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LAG-1 (Lymphocyte activation gene-1 protein, CCL4L1)
LAG-1 (Lymphocyte activation gene-1 protein, CCL4L1)
Pricing
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| Lymphocyte activation gene-1 protein (LAG-1) ia a CC chemokine and is part of the MIP-1 beta family. LAG-1 is identical to MIP-beta (ACTII isotype) except for two amino acid substitutions; arginine for histidine at position 22 and serine for glycine at position 47 of the mature protein. Like MIP-1 beta, it shows in ammatory and chemokinetic properties. Lag-1 binds to both CCR5 and to CCR8. Studies have shown that LAG-1 plays an essential role in HIV suppressive factors. Recombinant Human LAG-1 is a 7.7kDa protein containing 69 amino acid residues. | | | Catalog # | L1050 | | Stability | The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted LAG-1 should be stored in working aliquots at -20°C. | | Purity | 98% by SDS-PAGE and HPLC analyses | | Endotoxin | 0.1ng/ug (1EU/ug) | | Reconstitution | We recommend a quick spin followed by reconstitution in water to a concentration of 0.1–1.0 mg/ml. This solution can then be diluted into other buffers and stored at 4°C for 1 week or stored at -20°C for future use. | | Biological Activity | Determined by it’s ability to chemoattract CCR5 transfected cells using a concentration of 0.1–10.0ng/ml | | AA Sequence | APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRSKQV CADPSESWVQ EYVYDLELN | | Country of Origin | USA | | Source | E. coli | | Form | The sterile ltered solution was lyophilized with no additives. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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