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Specifications

Clone Host Grade Applications Monoclonal Mouse Supernatant B IH IF

Nuclear Lamins, also known as Class V intermediate filaments, are fibrous proteins providing structural function and transcriptional regulation in the cell nucleus. Nuclear lamins interact with membrane-associated proteins to form the nuclear lamina on the interior of the nuclear envelope. They are involved in the breakdown and reformation of the nuclear envelope during mitosis, as well as the positioning of nuclear pores.
Catalog #	L1219-90C
	Specificity X67 X167 X223Xenopus laevis LA, LI, LII LA, LII LII, LIIIBovine LA, C LA, B1, B2, C LB1, B2Mouse ND ND LB2Rat -- -- +Human LA, C LA, C LB1, B2Trout LA, LI, LII LA, LII, (LI) LII, LIIIRat kangaroo -- -- LII, LIII
Applications	Suitable for use in Immunofluorescence, Western Blot, and Immunohistochemistry. Other applications not tested.
Recommended Dilution	Immunohistochemistry: Neat
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	Mixed
Host	Mouse
Concentration	Not determined
Form	Supplied as a liquid, 0.09% sodium azide.
Purity	Supernatant
Immunogen	Nuclear pore complex-lamina fraction of Xenopus laevis (XLKE-A6 cells).
Specificity	Recognizes the karyoskeleton, ie the intermediate filament proteins of the nucleus. Reacts with Lamin isotypes of 60-75kD.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.