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Specifications

Clone Host Grade Applications Monoclonal Mouse Purified B IH IC

Nuclear lamins form a network of filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished: A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Type A lamins comprise a set of three proteins arising from the same gene by alternative splicing: lamins A, C, and Adel 10. B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Mutations in A-lamins give rise to a range of genetic disorders, including autosomal dominant Emery-Dreifuss muscular dystrophy (AD-EDMD), dilated cardiomyopathy and Dunnigan-type familial partial lipodystrophy. Aberrant expression patterns of nuclear lamins have been described in various types of cancer depending on the subtype of cancer, its aggressiveness, proliferative capacity and degree of differentiation. In general, the expression of A-type lamins (lamins A and C) has been correlated with a non-proliferating, differentiated state of cells and tissues. Lamins A and C, the products of the LMNA gene, are nuclear intermediate filament proteins and are the major structural components of the lamina network that underlies and supports the nuclear envelope. Expression of A-lamin coincides with cell differentiation and may be related protein’s abnormal expression and organization in neoplastic tissues and cells.
Catalog #	L1220-06
Applications	Western Blot
	Immunocytochemistry on fixed cells (methanol/acetone fixation)
	Immunohistochemistry on frozen tissue sections.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG3
Clone No	2Q1132
Host	Mouse
Source	Human
Concentration	~1mg/ml
Form	Supplied as a liquid in buffer containing 0.1% sodium azide.
Purity	Purified culture supernatant
Specificity	Human, rat, mouse, bovine and canine. lamin A. Recognizes an epitope between amino acids 598–611. Reactivity with other species has not yet been tested
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.