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Specifications

Clone Host Grade Applications Monoclonal Rat Supernatant IH

Laminins are large heterotrimeric, noncollagenous glycoproteins composed of alpha, beta and gamma chains. They are ubiquitously present in basement membrane (BM) along with entactin/nidogen (EN), collagen type IV (CIV) and large heparan sulfate proteoglycan (HSPG), which interact specifically with each other to form a continuous and regular BM. Alterations of BM integrity, from local discontinuities up to complete loss, are described in many types of human and animal epithelial neoplasms.
Catalog #	L1225-01F
Applications	Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution	Immunohistochemistry (Frozen): Pretreatment of the sections with pepsin is recommended.
	Optimal dilutions to be determined by the researcher.
	Storage and Stability:
	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	MEC5
Host	Rat
Source	Rat
Concentration	Not determined
Form	Supplied as a liquid, 0.05% sodium azide.
Purity	Supernatant
Immunogen	Derived from DZB rats that had developed a membranous glomerulopathy upon exposure to mercuric chloride (1).
Specificity	Recognizes rat Laminin. Directed against the P1 fragment of Laminin. Species Crossreactivity: mouse, human
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.