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You are here:Home » Antibodies » Abs to Extracellular Matrix Proteins » Anti -Laminin

Anti -Laminin

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites E B IP IF
Laminins are large heterotrimeric, noncollagenous glycoproteins composed of alpha, beta and gamma chains. Epithelial sheets in vivo are separated from the mesenchymal elements of the stroma by a thin layer of a specialized type of extracellular matrix termed the basement membrane (BM). This structure consists of individual components, some of which are ubiquitous in BMs and some are not. The ubiquitous ones comprise laminin (LN), entactin/nidogen (EN), collagen type IV (CIV), and large heparan sulfate proteoglycan (HSPG), which interact specifically with each other to form a continuous and regular BM. Alterations of BM integrity, from local discontinuities up to complete loss, are described in many types of human and animal epithelial neoplasms.
Catalog #L1225-21
ApplicationsSuitable for use in Immunofluorescence, ELISA, Western Blot, Immunoprecipitation and Affinity Chromatography. Other applications not tested.
Recommended DilutionsELISA (50% maximal binding to human laminin):
> 1:1,600,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No2Q596
HostMouse
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid. Preservative free
PurityAscites
ImmunogenPurified human laminin
SpecificityRecognizes the B1 portion of intact human laminin and blocks the neurite stimulating activity of laminin. No crossreactivity with mouse laminin.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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