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You are here:Home » Antibodies » Abs to Extracellular Matrix Proteins » Anti -Laminin S

Anti -Laminin S

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP
Extracellular matrix (ECM) surrounds and separates most tissue compartments, determines tissue architecture and dynamically interacts with its surrounding cells. The basement membrane is a part of the ECM and is composed of collagens, proteoglycans, elastin and several glycoproteins of which laminin is the most abundant. Laminins are large heterotrimeric, noncollagenous glycoproteins composed of alpha, beta, and gamma chains. Dystroglycan is a major laminin receptor in muscle and epithelia; and nidogen is a high affinity laminin binding protein important for basement membrane assembly. Alterations of BM integrity, from local discontinuities up to complete loss, are described in many types of human and animal epithelial neoplasms.
Catalog #L1225-28J
Cellular Localization Basement membrane.
Positive Control LS174T cells.
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No8L557
HostMouse
SourceBovine
Concentration~0.2mg/ml
Form10mM PBS, pH7.4, 0.2%BSA
PurityPurified by Protein G affinity chromatography.
ImmunogenBovine anterior lens capsule.
SpecificitySpecies Crossreactivity: Crossreacts with Human, Rat, bovine, Pig, Guinea pig and Chicken.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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