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You are here:Home » Antibodies » Abs to Extracellular Matrix Proteins » Anti -Laminin (LAMA1, LAMA, Laminin A Chain, Laminin alpha 1 Chain)

Anti -Laminin (LAMA1, LAMA, Laminin A Chain, Laminin alpha 1 Chain)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant IH
Laminin is a basic component of basement membranes that mediates a number of biological functions such as cell adhesion, growth, migration and differentiation. It has been shown to bind to cells through membrane receptors. It is a very complex protein composed of three chains that form a cruciform structure with three short arms and one long arm. The molecule has one heavy (A) chain (Mr approx. 400kD) and two light (B) chains (Mr Approx.200kD). Furthermore, there are three types of light chains, B1, B2 and s-laminin. All the chains contain globular domains, rod-like domains with cysteine-rich repeats and an azhelical domain that participates in the triple coiled-coil structure forming the long arm of the molecule. Additionally, the A chain has a large C-terminal globule, termed domain G. The gene encoding the laminin protein maps to 18p11.31 region of human chromosome.
Catalog #L1225-30A
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 1:5-1:20
Optimal dilutions to be determined by the researcher.
Positive ControlSkin
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a,k
Clone No11E256
HostMouse
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.05% sodium azide.
PuritySupernatant
ImmunogenA chain of human laminin. Cellular Localization: Basement membrane.
SpecificityRecognizes the terminal globular domain of the A chain of human Laminin.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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