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You are here:Home » Molecular Biology » MB-Protein Kinase Inhibitors » Lapatinib, Di-p-Toluenesulfonate Salt (N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine Ditosylate, Lapatinib Ditosylate, Tykerb, GW-572016, Tyverb)

Lapatinib, Di-p-Toluenesulfonate Salt
(N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]f
uran-2-yl]quinazolin-4-amine Ditosylate, Lapatinib Ditosylate, Tykerb, GW-572016, Tyverb)

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Specifications

Lapatinib inhibits both epidermal growth factor receptor (EGFR) and HER2/neu (ErbB-2) tyrosine kinases by binding to the intracellular phosphorylation domain, preventing receptor autophosphorylation. The exact site of binding has currently not been confirmed. It appears to arrest the development of breast cancer in some patients with metastatic, treatment-refractory disease.
Catalog #L1315-50
SolubilitySoluble in DMSO at 200mg/ml; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 1-10uM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
Elemental AnaylsisCalculated:
C=54.22%
H=4.76%
Cl=3.72%
F= 1.99%
N=5.88%
S= 10.10%
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 6 months.
CAS Number388082-78-8
Molecular FormulaC29H26ClFN4O4S2C7H8O3S
Molecular Weight925.46
Purity~99%
FormSupplied as a yellow powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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