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You are here:Home » Biochemicals » Biochem-Drugs/Analogues » Lapatinib, Free Base (N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine, GSK 572016, GW-572016, GW 572016X, Tykerb, Tyverb)

Lapatinib, Free Base
(N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]meth
yl]-2-furanyl]-4-quinazolinamine, GSK 572016, GW-572016, GW 572016X, Tykerb, Tyverb)

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Specifications

Lapatinib (as the di-p-toluenesulfonate salt) is the active ingredient in the drug sold under the trade names Tykerb in the US and Tyverb in Europe. This drug has been approved in at least one country to treat advanced metastatic breast cancer in conjunction with the chemotherapy drug Xeloda (generic name, capecitabine).
Catalog #L1315-51
SolubilitySoluble in DMSO at 200mg/ml; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 1-10uM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
Melting Point 142-144ºC
Storage and StabilityMay be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
CAS Number231277-92-2
Molecular FormulaC29H26ClFN4O4S
Molecular Weight581.06
Purity>99%
FormSupplied as a pale yellow powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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