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Specifications

Clone Host Grade Applications Polyclonal Human Purified E IP

The La/SS-B antigen is a 47kD ribonucleic protein that is associated with a spectrum of small RNAs (2). La/SS-B appears to be readily susceptible to proteolysis, resulting in many smaller (42, 320, and 270kD) but still immunoreactive polypeptides (3). It has been shown that the La/SS-B antigen primarily resides in the nucleus (2). It appears to be associated with RNA polymerase III transcripts (4). It has also been shown that the La/SS-B antigen shows strong conservation across species (5). Anti-La/SS-B autoantibodies were described originally as precipitating autoantibodies in sera of Sjogren's Syndrome patients and referred to as SjT(1). A precipitin with the same properties was rediscovered later and termed La and then SS-B. Anti-La/SS-B precipitins. The presence of autoantibodies against the La/SS-B antigen has been advocated as a diagnostic aid in Sjogren's Syndrome patients (6). Autoantibodies against La/SS-B are also commonly found in Systemic Lupus Erythematosus and Subacute Cutaneous Lupus (4). In addition, there appears to be a correlation between anti-La/SS-B and the absence of nephritis in SLE patients. Studies have demonstrated that SLE patients with precipitating Anti-Ro/SS-A antibodies have a high incidence of serious nephritis (53%), while those with both Anti-Ro/SS-A and Anti-La/SS-B have a low (9%) frequency of nephritis (7).
Catalog #	L1380
Applications	Suitable for use in ELISA, Immunodiffusion and Immunoprecipitation. Other applications not tested.
Recommended Dilution	ELISA: 1:100
	Optimal dilutions to be determined by the researcher.
Storage and Stability	Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Human
Source	Human
Concentration	Not determined
Form	Supplied as a lyophilized powder from 0.01 M PBS, 0.02% sodium azide. Reconstitute with 2ml sterile ddH2O.
Purity	Purified by fractionation of delipidated and defibrinated donor human serum.
Immunogen	Purified from donor human serum.
Specificity	Recognizes human La/SS-B. Specificity is verified by a precipitin line of identity with the CDC-AF reference serum. Crossreactivity
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.