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Anti -LAT, phosphorylated (Tyr132) (Linker for activation of T Cells)
Anti -LAT, phosphorylated (Tyr132) (Linker for activation of T Cells)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
|
| Linker for activation of T cells (LAT) is a 36kD transmembrane adapter protein that is tyrosine-phosphorylated following T-cell receptor (TCR) stimulation by ZAP-70 and Syk. Four distal tyrosine residues (Y132, Y171, Y191 and Y226 in human LAT) are crucial for its activity and subsequent signaling to downstream molecules. Tyrosine 132 mediates LAT binding to PLC-y-1 and is necessary for TCR-mediated calcium mobilization and activation of ERK and NFAT proteins. | | | Catalog # | L1390-01C | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 0.1-1ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | Jurkat E6.1 cells | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid in PBS (without Mg2+ and Ca2+), 1mg/ml BSA (IgG, protease free), pH 7.2, 0.05% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic phosphopeptide derived from a region of human LAT that contains tyrosine 132. | | Specificity | Recognizes human LAT when phosphorylated at Tyr132. Species sequence homology: mouse (85%) and rat (77%). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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