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Anti -LAT, phosphorylated (Tyr191) (Linker for activation of T Cells)
Anti -LAT, phosphorylated (Tyr191) (Linker for activation of T Cells)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
|
| Linker for activation of T cells (LAT) is a 36kD transmembrane adapter protein that is tyrosinephosphorylated following T-cell receptor (TCR) stimulation by ZAP-70 and Syk. Four distal tyrosine residues (Y132, Y171, Y191 and Y226 in human LAT) are crucial for its activity and subsequent signaling to downstream molecules. Tyrosine 191 has been shown to play a key role in T cell activation and to mediate Grb2 binding and Gads recruitment, thus mediating SLP-76 binding. | | | Catalog # | L1390-02A | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 0.1-1ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | Stimulated Jurkat E6.1 | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS (without Mg2+ and Ca2+), 1mg/ml BSA (IgG, protease free), pH 7.3, 0.05% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic phosphopeptide derived from a region of human LAT that contains tyrosine 191. | | Specificity | Recognizes human LAT when phosphorylated at Tyr191. Species sequence homology: mouse and rat (92%). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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