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You are here:Home » Antibodies » Abs to Tumor Suppressors » Anti -LATS2 (Large Tumor Suppressor Homolog 2, LATS-2, Kinase Phosphorylated During Mitosis, KPM, Serine/Threonine Protein Kinase kpm, Warts-like Kinase)

Anti -LATS2 (Large Tumor Suppressor Homolog 2, LATS-2, Kinase Phosphorylated During
Mitosis, KPM, Serine/Threonine Protein Kinase kpm, Warts-like Kinase)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.
Catalog #L1397-85
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormTris-citrate/phosphate pH 7-8
PurityPurified by immunoaffinity chromatography.
ImmunogenThe epitope that this antibody recognizes maps to a region between residues 1 and 50 of human Large Tumor Suppressor 2 using the numbering given in entry NP_055387.1.
SpecificityRecognizes human LATS2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesLATS 2, LATS-2, Large Tumor Suppressor 2


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