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You are here:Home » Antibodies » Abs to Tumor Suppressors » Anti -LATS2 (Large Tumor Suppressor Homolog 2, LATS-2, Kinase Phosphorylated During Mitosis, KPM, Serine/Threonine Protein Kinase kpm, Warts-like Kinase)

Anti -LATS2 (Large Tumor Suppressor Homolog 2, LATS-2, Kinase Phosphorylated During
Mitosis, KPM, Serine/Threonine Protein Kinase kpm, Warts-like Kinase)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.
Catalog #L1397-85
ApplicationsSuitable for use in Western Blot, Immunoprecipitation and Proximity Ligation Assay. Other applications not tested.
Recommended DilutionsWestern Blot: 1:1000-1:5000
Immunoprecipitation: 2-5ug/mg
Proximity Ligation Assay: 1:1000-1:20000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.    
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
PurityPurified by immunoaffinity chromatography.
ImmunogenThe epitope that this antibody recognizes maps to a region between residues 1 and 50 of human Large Tumor Suppressor 2 (NP_055387.1).
SpecificityRecognizes human LATS2. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesLATS 2, LATS-2, Large Tumor Suppressor 2


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