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You are here:Home » Antibodies » Abs to Adapter Proteins » Anti -LAX1 (Lymphocyte Transmembrane Adapter 1, Linker for Activation of X Cells, Membrane-associated Adapter Protein LAX, LAX)

Anti -LAX1 (Lymphocyte Transmembrane Adapter 1, Linker for Activation of X Cells,
Membrane-associated Adapter Protein LAX, LAX)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E
LAX1 (Linker for activation of X cells) is a 70kD member of a small group of T cell transmembrane (TM) adaptor proteins. It is upregulated on both T and B cells after activation, and likely downmodulates both BCR and TCR signaling. Human LAX1 is 398aa in length. Although its predicted MW is 44kD, it runs anomalously at 70kD in SDS-PAGE. It is a type III (no signal sequence) TM protein that contains a 37aa N-terminal extracellular region and a 340aa cytoplasmic domain (aa59-398). There are two potential isoform variants. One has an alternate start site at Met77, while a second shows a 13aa substitution for aa1-29. Over aa136-398, human LAX1 is 47% aa identical to mouse LAX1.
Catalog #L1440-01A
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:32,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-PLLTLPQTRQRA, from human LAX1, at the internal region of the protein (NP_060243.2, NP_001129662.1).
SpecificityRecognizes human LAX1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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