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Anti -LAX1 (Lymphocyte Transmembrane Adapter 1, Linker for Activation of X Cells, Membrane-associated Adapter Protein LAX, LAX)
Anti -LAX1 (Lymphocyte Transmembrane Adapter 1, Linker for Activation of X Cells,
Membrane-associated Adapter Protein LAX, LAX)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E |
|
| LAX1 (Linker for activation of X cells) is a 70kD member of a small group of T cell transmembrane (TM) adaptor proteins. It is upregulated on both T and B cells after activation, and likely downmodulates both BCR and TCR signaling. Human LAX1 is 398aa in length. Although its predicted MW is 44kD, it runs anomalously at 70kD in SDS-PAGE. It is a type III (no signal sequence) TM protein that contains a 37aa N-terminal extracellular region and a 340aa cytoplasmic domain (aa59-398). There are two potential isoform variants. One has an alternate start site at Met77, while a second shows a 13aa substitution for aa1-29. Over aa136-398, human LAX1 is 47% aa identical to mouse LAX1. | | | Catalog # | L1440-01A | | Applications | Suitable for use in ELISA. Other applications not tested. | | Recommended Dilution | ELISA: 1:32,000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to C-PLLTLPQTRQRA, from human LAX1, at the internal region of the protein (NP_060243.2, NP_001129662.1). | | Specificity | Recognizes human LAX1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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