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You are here:Home » Antibodies » Antibodies-Peptides » Anti -Liver-expressed Antimicrobial Peptide 2 (LEAP-2)

Anti -Liver-expressed Antimicrobial Peptide 2 (LEAP-2)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Human genome contains numerous genes whose protein products are unknown in terms of structure, interaction partner, expression, and function.
Catalog #L1600-20B
From human blood ultrafiltrate, a novel gene-encoded, cysteine-rich, and cationic peptide termed as liver- expressed antimicrobial peptide 2 (LEAP-2) together with several circulating forms of LEAP-2 differing in their amino-terminal length were identified, all containing a core structure with two disulfide bonds formed by cysteine residues in relative 1-3 and 2-4 positions. The largest native LEAP-2 form of 40aa residues is generated from the precursor at a putative cleavage site for a furin-like endoprotease. In contrast to smaller LEAP-2 variants, this peptide exhibited dose-dependent antimicrobial activity against selected microbial model organisms.
LEAP2 rat= 75aa; mouse= 76aa; human= 77aa; Human chromosome: 5q31.1. Protein homology between mose, rat and human LEAP2 is 99%. LEAP2 is expressed in liver, blood, urine and kidney.
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:100,000 (50-100ng control peptide/well)
Western Blot: 1-10ug/ml (chemiluminescence)
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
ConcentrationAs reported
FormSupplied as a lyophilized powder from PBS, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 20aa of human LEAP-2 (Accession #Q969E1) (KLH).
SpecificityRecognizes human LEAP-2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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