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You are here:Home » Antibodies » Abs to Obesity Proteins » Anti -Leptin (LEP, Leptin Murine Obesity Homolog, Leptin Precursor Obesity Factor, Ob, Obese Protein, Obesity, Obesity Factor, Obesity Homolog Mouse, OBS)

Anti -Leptin (LEP, Leptin Murine Obesity Homolog, Leptin Precursor Obesity Factor, Ob,
Obese Protein, Obesity, Obesity Factor, Obesity Homolog Mouse, OBS)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse E
Leptin (from the Greek leptos, meaning thin) is a protein hormone with important effects in regulating body weight, metabolism and reproductive function. The protein is approximately 16kD in mass and encoded by the obese (ob) gene. Leptin is expressed predominantly by adipocytes, which fits with the idea that body weight is sensed as the total mass of fat in the body. Smaller amounts of leptin are also secreted by cells in the epithelium of the stomach and in the placenta. Leptin receptors are highly expressed in areas of the hypothalamus known to be important in regulating body weight, as well as in T lymphocytes and vascular endothelial cells. Leptin's effects on body weight are mediated through effects on hypothalamic centers that control feeding behavior and hunger, body temperature and energy expenditure.
Catalog #L1670-12
Cellular Localization Secreted
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No8L577
HostMouse
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2.
PurityAs reported
ImmunogenRecombinant full length protein.
SpecificityThis antibody recognizes recombinant human leptin and leptin circulating in human blood. Species Crossreactivity: Crossreacts with Human. Not yet tested in other species, but may be crossreactive to mouse and rat due to 85% and 84% homology to human leptin respectively.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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