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You are here:Home » Biochemicals » Biochem-Antibiotics » Leptomycin A (Antibiotic ATS 1287A, Antibiotic PD 118607, Jildamycin)

Leptomycin A (Antibiotic ATS 1287A, Antibiotic PD 118607, Jildamycin)


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Leptomycin A, a methyl (cf. ethyl) analogue of Leptomycin B, is a minor component of the leptomycin complex produced by selected Streptomyces species. Leptomycin B is a potent inhibitor of the nuclear transport receptor CRM1. Leptomycin A is also likely to inhibit nuclear transport and may offer differences in exporter selectivity. Leptomycin A shows antimicrobial activity against Schizosaccaromyces pombe and Mucor rouxianus.
Catalog #L1671-38
Purity >99% by HPLC
Solubility Soluble in ethanol or methanol. Ethanol recommended. Unstable in DMSO.
Related to Anguinomycin A, Leptomycin B, Kazusamycin A, Kazusamycin B,
CAS Number87081-36-5
Molecular FormulaC32H46O6
Molecular Weight526.7
SourceStreptomyces sp.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesAntibiotic ATS 1287A, Antibiotic PD 118607, Jildamycin

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