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Leptomycin A (Antibiotic ATS 1287A, Antibiotic PD 118607, Jildamycin)
Leptomycin A (Antibiotic ATS 1287A, Antibiotic PD 118607, Jildamycin)
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| Leptomycin A, a methyl (cf. ethyl) analogue of Leptomycin B, is a minor component of the leptomycin complex produced by selected Streptomyces species. Leptomycin B is a potent inhibitor of the nuclear transport receptor CRM1. Leptomycin A is also likely to inhibit nuclear transport and may offer differences in exporter selectivity. Leptomycin A shows antimicrobial activity against Schizosaccaromyces pombe and Mucor rouxianus. | | | Catalog # | L1671-38 | | Purity | >99% by HPLC | | Solubility | Soluble in ethanol or methanol. Ethanol recommended. Unstable in DMSO. | | Related to | Anguinomycin A, Leptomycin B, Kazusamycin A, Kazusamycin B, | | CAS Number | 87081-36-5 | | Molecular Formula | C32H46O6 | | Molecular Weight | 526.7 | | Source | Streptomyces sp. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Antibiotic ATS 1287A, Antibiotic PD 118607, Jildamycin |
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