Leptomycin B (Elactocin, Antibiotic ATS 1287B, Antibiotic CI 940, Antibiotic CL 1957A,
Antibiotic PD 114720, Mantuamycin)
Pricing
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| Leptomycin B is the dominant and most studied member of the leptomycin class isolated from selected Streptomyces strains. Leptomycin B is a nanomolar active and specific nuclear export inhibitor. Its target is CRM1/exportin1 a protein in the nuclear export sequence (NES). Examples of proteins affected are c-Abl, cyclin B1, HIV-1 Rev, I B, MPF, MAP/ERK, MDM2/p53, NF- B/I B7 and PKA. Export of many RNAs are also inhibited e.g. COX-2 and c-FOS mRNA. In addition Leptomycin B shows antifungal and antibacterial and potent antitumour activities. | | | Catalog # | L1671-38A | | Purity | >99% by HPLC | | Form | Colorless film | | Solubility | Soluble in ethanol or methanol. Ethanol is recommended. Unstable in DMSO. | | Storage and Stability | Stable for 6 months at -20°C. | | Related to | Anguinomycin A, Leptomycin A, Kazusamycin A, Kazusamycin B | | CAS Number | 87081-35-4 | | Molecular Formula | C33H48O6 | | Molecular Weight | 540.7 | | Source | Streptomyces sp. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Elactocin, Antibiotic ATS 1287B, Antibiotic CI 940, Antibiotic CL 1957A, Antibiotic PD 114720, Mantuamycin |
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