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You are here:Home » Biochemicals » Biochem-Antibiotics » Leptomycin B (Elactocin, Antibiotic ATS 1287B, Antibiotic CI 940, Antibiotic CL 1957A, Antibiotic PD 114720, Mantuamycin)

Leptomycin B (Elactocin, Antibiotic ATS 1287B, Antibiotic CI 940, Antibiotic CL 1957A,
Antibiotic PD 114720, Mantuamycin)

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Specifications

Leptomycin B is the dominant and most studied member of the leptomycin class isolated from selected Streptomyces strains. Leptomycin B is a nanomolar active and specific nuclear export inhibitor. Its target is CRM1/exportin1 a protein in the nuclear export sequence (NES). Examples of proteins affected are c-Abl, cyclin B1, HIV-1 Rev, I B, MPF, MAP/ERK, MDM2/p53, NF- B/I B7 and PKA. Export of many RNAs are also inhibited e.g. COX-2 and c-FOS mRNA. In addition Leptomycin B shows antifungal and antibacterial and potent antitumour activities.
Catalog #L1671-38A
Purity >99% by HPLC
Form Colorless film
Solubility Soluble in ethanol or methanol. Ethanol is recommended. Unstable in DMSO.
Storage and Stability Stable for 6 months at -20°C.
Related to Anguinomycin A, Leptomycin A, Kazusamycin A, Kazusamycin B
CAS Number87081-35-4
Molecular FormulaC33H48O6
Molecular Weight540.7
SourceStreptomyces sp.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesElactocin, Antibiotic ATS 1287B, Antibiotic CI 940, Antibiotic CL 1957A, Antibiotic PD 114720, Mantuamycin


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