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LY294002 2-(4-Morpholinyl)-8-phenyl-4H-1- benzopyran-4-one
LY294002 2-(4-Morpholinyl)-8-phenyl-4H-1- benzopyran-4-one
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| LY294002 is a potent and specific cell-permeable inhibitor of phosphatidylinositol 3-kinase (PI3-kinase). LY294002 at a concentration of 50uM completely abolishes the PI3-K activity of intact neutrophils stimulated with fMet-Leu-Phe, without apparent cell toxicity. While concentration of 50uM is observed to be efficacious for inhibiting PI3-K activity in stimulated neutrophils, this concentration produces no significant inhibition of other kinases including PKC, PKA, MAP kinase, S6 kinase, EGF receptor tyrosine kinase, Src, PI4-kinase, diacylglycerol kinase, or rabbit kidney ATPase. This compound is a useful tool for identifying cellular event that are regulated by the PI3-kinase/Akt axis and is observed to induce apoptosis in many cell types by blocking the PI3-kinase/Akt anti-apoptotic pathway. | | | Catalog # | L1756 | | Molecular Weight | ~307.4 | | Biological Activity | IC50=1.4uM | | Solubility | DMSO (~25mg/ml), warm ethanol (~25mg/ml) | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Formula | C19H17NO3 | | Molecular Weight | 307.4 | | Purity | ~99% (TLC) | | Concentration | Not determined | | Form | Supplied as a off-white to pale-yellow lyophilized powder. Reconstitute with sterile dH2O to 0.1-1mg/ml. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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