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You are here:Home » Antibodies » Abs to Carbohydrates, Glycoproteins » Anti -Leucine-rich alpha-2-glycoprotein (LRG, HMFT1766, Leucine-rich alpha-2-glycoprotein 1, LRG1)

Anti -Leucine-rich alpha-2-glycoprotein (LRG, HMFT1766, Leucine-rich alpha-2-glycoprotein
1, LRG1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
LRG1 is a 347aa containing leucine-rich secreted protein, belonging to leucine-rich repeat (LRR) family of proteins and contains eight LRR (leucine rich) repeats, a galactosamine and four glucosamine oligosaccharides attached and has two intrachain disulfide bonds. LRG1, a regulatory protein, is usually found in plasma and is expressed during granulocyte differentiation. Different functions of LRG1 include protein-protein interaction, signal transduction, cell adhesion and development. LRG1 expression is detected in neutrophil fraction of bone marrow and peripheral blood and in the bone marrow mononuclear cell fraction. LRG1 expression is usually upregulated in early DMSO-induced granulocyte differentiation of human promyelocytic leukemia HL-60 cells and also in GCSF-treated human cells derived from a patient with myeloproliferative disorder. Thus LRG1 acts as a novel marker for early neutrophilic granulocyte differentiation.
Catalog #L2020-67A
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 2-4ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHCT-116, colon
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa300-350 of human LRG1.
SpecificityRecognizes human LRG1. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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