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Anti -LSP1, Phosphorylated (Ser252) (Lymphocyte-specific Protein 1, 47kD Actin-binding Protein, 52kD Phosphoprotein, pp52, Lymphocyte-specific Antigen WP34, WP34)
Anti -LSP1, Phosphorylated (Ser252) (Lymphocyte-specific Protein 1, 47kD Actin-binding
Protein, 52kD Phosphoprotein, pp52, Lymphocyte-specific Antigen WP34, WP34)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
|
| Leukocyte-specific protein (LSP; also known as Lymphocyte- specific protein, SP34 and pp52) is a 52kD filamentous-actin- binding intracellular phosphoprotein. Human LSP1 is composed of 339aa, which expressed in normal and transformed B- lineage cells and normal T-lymphocytes. Studies show that LSP1 plays an important role in cytoskeletal architecture and motility regulation as well as receptor-induced apoptosis. Research show that LSP1 has at least three and potentially a fourth F-actin binding domain located in the basic C-terminal half. This F-actin binding sites are also correspond to the caldesmon and the villin headpiece proteins. LSP1 246-295 containing sequences homologous to caldesmon F-actin binding site II (CII) can bind F-actin. | | | Catalog # | L2030-01A | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 0.5-2ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide (RQA-pS-IEL) corresponding to the C-terminus of human LSP1 at the phosphorylated site of Serine 252. | | Specificity | Recognizes human LSP1, when phosphorylated at Serine 252. Species Crossreactivity: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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