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Anti -LSP1 (Lymphocyte-specific Protein 1, 47kD Actin-binding Protein, 52kD Phosphoprotein, pp52, Lymphocyte-specific Antigen WP34, WP34)
Anti -LSP1 (Lymphocyte-specific Protein 1, 47kD Actin-binding Protein, 52kD
Phosphoprotein, pp52, Lymphocyte-specific Antigen WP34, WP34)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E B |
|
| Leukocyte-specific protein (LSP; also known as Lymphocyte-specific protein1, SP34 and pp52) is a 52kd filamentous-actin-binding intracellular phosphoprotein. LSP is localized to the internal surface of the plasma membrane, cytoplasm, and actin filaments. LSP expressed in various eukaryotic cell lines such as the melanoma cell line A7 but not in other hematopoietic lineages. Studies showed that LSP play a key role in anti-IgM-induced apoptosis of the B-cell lymphoma line as well as cytoskeleton-driven regulation. LSP contains a high-affinity F-actin binding site, which recently is identified in the basic C-terminal half. | | | Catalog # | L2030-30C | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1:16,000 | | Western Blot: 0.05-0.2ug/ml, observed in human lymph node, tonsil and peripheral blood mononucleocytes lysates on ~50kD bands | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to C-RYKFVATGHGKYEKV, from LSP1, at C-terminal (NP_002330.1, NP_001013271.1). | | Specificity | Recognizes human LSP1. Species Crossreactivity | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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