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You are here:Home » Molecular Biology » MB-Protease Inhibitors » Leupeptin Hemisulfate

Leupeptin Hemisulfate


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Leupeptin is a reversible competitive inhibitor of serine and thiol proteases that
competes with substrate for the active site of the enzyme. It has been reported to
inhibit calpain, cathepsin B and trypsin, for example. Leupeptin is often used for the inhibition of plasmin, trypsin, papain, kallikrein and cathepsin B. No inhibition found with pepsin, cathepsins A and D, elastase, renin or chymotrypsin. A typical working concentration is in the range of 10-100uM
Catalog #L2050
Appearance White powder
Optical Rotation: -80.0° ± 2°
Water: 5%
Specific Activity (Trypsin/TAME): As Reported
Molecular Weight (Sulfate Form): (Ac-Leu-Leu-Argininal):
As Reported
Storage and StabilityLyophilized powder may be stored at -20°C. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Product is stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
NoteLeupeptin has 3 tautomeric isomers which are separated by chromatography.
CAS Number103476-89-7
Molecular FormulaC20H38N6O41/2H2SO4
Molecular Weight426.55
FormWhite powder
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesMicrobial

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