Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to RNA Processing » Anti -Lin28b (Protein Lin-28 Homolog B, Lin-28B, Lin-28.2)

Anti -Lin28b (Protein Lin-28 Homolog B, Lin-28B, Lin-28.2)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
LIN28A and LIN28B are conserved, developmentally regulated RNA binding proteins that inhibit the processing and maturation of the let-7 family of miRNAs (1,2). The let-7 miRNAs have been implicated in repression of oncogenes such as ras, myc and Hmga2 (3). It has recently been shown that LIN28A and LIN28B are upregulated in primary human tumors and in human cancer cell lines, their overexpression directly correlating to downregulation of let-7 miRNAs (4). LIN28 genes are reported to be involved in primordial germ cell development and germ cell malignancy (5), and allelic variation in LIN28B is associated with regulating the timing of puberty in humans (6). Overexpression of LIN28A, in conjunction with Oct-4, Sox2 and Nanog, can reprogram human fibroblasts to pluripotent, ES-like cells (7).
Catalog #L2279-95
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
ConcentrationNot determined
FormSupplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide corresponding to residues near the carboxy terminus of mouse LIN28B. Species sequence homology: rat
SpecificityRecognizes endogenous levels of total mouse LIN28B protein.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesLin-28 Homolog B (C. elegans), 2810403D23Rik, D030047M17Rik


External Links