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Specifications

Clone Host Grade Applications Monoclonal Mouse Purified E

Pancreatic lipase (PNLIP) fulfills a key function in dietary fat absorption by hydrolyzing triglycerides into diglycerides and subsequently into monoglycerides and free fatty acids. By screening a human pancreas cDNA library with degenerate oligonucleotides designed from the amino acid sequences of human, canine, and porcine PNLIP, Giller et al. (1992) isolated cDNAs encoding 2 novel PNLIP-related proteins, PNLIPRP1 (604422) and PNLIPRP2, which they called PLRP1 and PLRP2, respectively. The predicted 469-amino acid PNLIPRP2 protein contains a 17-amino acid signal peptide and the conserved residues of the lipase catalytic triad and oxy-anion hole. Among known lipases, PNLIPRP2 was most related to a mouse T-cell lipase, with 74% amino acid identity. PNLIPRP2 has 65% amino acid sequence identity with PNLIP, 63% identity with PNLIPRP1, and 20 to 30% identity with human gastric lipase, lipoprotein lipase, and hepatic lipase.
Catalog #	L2496
Applications	Suitable for use in ELISA or antigenic applications in immunological protocols. Other applications not tested.
Recommended Dilutions	Optimal dilutions to be determined by the researcher.
Affinity Constant	~1.1x10e9L/mole
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	8.F.195
Host	Mouse
Source	Human
Concentration	~1mg/ml
Form	Supplied as a liquid in PBS, 0.1% sodium azide.
Purity	Purified by column chromatography.
Immunogen	Human Pancreatic Lipase.
Specificity	Recognizes human pancreatic lipase. Species Sequence Homology: porcine, rat and mouse.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.