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You are here:Home » Antibodies » Abs to Receptors » Anti -low density lipoprotein receptor-related protein 4 (LRP4, KIAA0816, LRP10, MEGF7, low-density lipoprotein receptor-related protein 4)

Anti -low density lipoprotein receptor-related protein 4 (LRP4, KIAA0816, LRP10, MEGF7,
low-density lipoprotein receptor-related protein 4)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
Low-density lipoprotein receptor-related protein 4 (LRP-4) is a novel, single-pass type I membrane protein belonging to the LDLR family and is comprised of three EGF-like domains, eight LDL-receptor class A domains, and twenty LDL-receptor class B repeats. The exact function of LRP-4 has yet to be elucidated, however it is thought to function as a cell surface receptor with the ability to both bind and neutralize extracellular ligands, internalizing them for lysosomal degradation. Expression has been observed in various regions of the brain.
Catalog #L2601-04D
ApplicationsSuitable for use in Immunohistochemistry. Other applications have not been tested.
Recommended Dilutions
Immunohistochemistry: 1:500 detects LRP-4 in normal human brain tissue.
Optimal dilutions to be determined by the researcher.
Positive ControlNormal human brain tissue
Molecular Weight212 kDa calculated. It has been reported that transfection of LRP-4 reveals different protein products at 20 kDa, 75 kDa and 250 kDa. While the 250 kDa band represents full length LRP-4, the two smaller bands appear to be processing products of the receptor. No bands were detected in the untransfected conditions. (Dietrich, M.F., et al. (2010). PLoS ONE 5(4):e9960:1-7.)
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
PurityPurified by affinity chromatography.
ImmunogenLinear peptide corresponding to human LRP-4 at the cytoplasmic domain (KLH).
SpecificityRecognizes human LRP-4. Species crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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