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You are here:Home » Antibodies » Abs to Leukotrienes » Anti -LOX-1 (CLEC8A, hLOX-1, Lectin-like oxidized LDL receptor 1, Lectin-like oxLDL receptor 1, Lectin-type oxidized LDL receptor 1, LOX1, LOX-1, oxidised low density lipoprotein (lectin-like) receptor 1, Oxidized low-density lipoprotein receptor 1, Ox-LDL rece

Anti -LOX-1 (CLEC8A, hLOX-1, Lectin-like oxidized LDL receptor 1, Lectin-like oxLDL
receptor 1, Lectin-type oxidized LDL receptor 1, LOX1, LOX-1, oxidised low density
lipoprotein (lectin-like) receptor 1, Oxidized low-density lipoprotein receptor 1, Ox-LDL
rece

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified FC N
LOX-1 belongs to the C-type lectin-like protein superfamily. This unique scavenger receptor plays important roles in atherogenesis. Like other scavenger receptors, LOX-1 has a wide spectrum of physiological ligands, including OxLDL, anionic phospholipids, aged/apoptotic cells, activated platelets, and bacteria. The LOX-1 gene is a so-called immediate early gene that is dynamically modulated by several factors in vitro and in vivo. LOX-1 expression is induced by stimuli such as inflammatory cytokines, OxLDL, TNF-alpha, TGF-beta, and ANG II in vitro, and several proatherogenic factors in vivo. Monoclonal antibody neutralizes LOX-1 and inhibits Hsp70 binding to dendritic cells and Hsp70-induced antigen cross-presentation. In vivo, targeting LOX-1 with a tumor antigen using anti-LOX-1 antibody induces antitumor immunity.
Catalog #L2623-01
ApplicationsSuitable for use in flow cytometry and for neutralization of the biological activity of LOX-1. Other applications not tested.
Recommended DilutionFlow Cytometry: 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No9G218
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.1% BSA.
PurityPurified
ImmunogenFusion protein of extracellular domain (aa 71-273) of human LOX-1 with murine Fc 1 (LOX-1-muFc) produced in PEAK cells
SpecificityRecognizes lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesSCARE1, CLEC8A, OLR1


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