Anti -LOX-1 (CLEC8A, hLOX-1, Lectin-like oxidized LDL receptor 1, Lectin-like oxLDL
receptor 1, Lectin-type oxidized LDL receptor 1, LOX1, LOX-1, oxidised low density
lipoprotein (lectin-like) receptor 1, Oxidized low-density lipoprotein receptor 1, Ox-LDL
rece
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
FC IF N |
|
| LOX-1 belongs to the C-type lectin-like protein superfamily. This unique scavenger receptor plays important roles in atherogenesis. Like other scavenger receptors, LOX-1 has a wide spectrum of physiological ligands, including OxLDL, anionic phospholipids, aged/apoptotic cells, activated platelets, and bacteria. The LOX-1 gene is a so-called immediate early gene that is dynamically modulated by several factors in vitro and in vivo. LOX-1 expression is induced by stimuli such as inflammatory cytokines, OxLDL, TNF-alpha, TGF-beta, and ANG II in vitro, and several proatherogenic factors in vivo. L2623-01A neutralizes LOX-1 and inhibits Hsp70 binding to dendritic cells and Hsp70-induced antigen cross-presentation. In vivo, targetting LOX-1 with a tumor antigen using anti-LOX-1 antibody induces antitumor immunity. | | | Catalog # | L2623-01A | | Applications | Suitable for use in Flow Cytometry, Immunofluorescence, Neutralization and functional studies. Other applications not tested. | | Recommended Dilution | Flow Cytometry: 1:50. 10ug/ml was used on human peripheral blood myeloid DC and macrophages. | | Fuctional studies: totally prevents Hsp70 binding to LOX-1-CHO but not mock-transfected CHO cells (1). | | Optimal dilutions to be determined by the researcher. | | Positive Control | Human APCs | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 9G219 | | Host | Mouse | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide. Labeled with Biotin. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Fusion protein corresponding to the extracellular domain, aa71-273, of human LOX-1 with mouse Fcy1 (LOX-1-muFc) produced in PEAK cells. | | Specificity | Recognizes human lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1). Species crossreactivity: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | SCARE1, CLEC8A, OLR2 |
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