Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Leukotrienes » Anti -LOX-1 (CLEC8A, hLOX-1, Lectin-like oxidized LDL receptor 1, Lectin-like oxLDL receptor 1, Lectin-type oxidized LDL receptor 1, LOX1, LOX-1, oxidised low density lipoprotein (lectin-like) receptor 1, Oxidized low-density lipoprotein receptor 1, Ox-LDL rece

Anti -LOX-1 (CLEC8A, hLOX-1, Lectin-like oxidized LDL receptor 1, Lectin-like oxLDL
receptor 1, Lectin-type oxidized LDL receptor 1, LOX1, LOX-1, oxidised low density
lipoprotein (lectin-like) receptor 1, Oxidized low-density lipoprotein receptor 1, Ox-LDL
rece

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified FC IF N
LOX-1 belongs to the C-type lectin-like protein superfamily. This unique scavenger receptor plays important roles in atherogenesis. Like other scavenger receptors, LOX-1 has a wide spectrum of physiological ligands, including OxLDL, anionic phospholipids, aged/apoptotic cells, activated platelets, and bacteria. The LOX-1 gene is a so-called immediate early gene that is dynamically modulated by several factors in vitro and in vivo. LOX-1 expression is induced by stimuli such as inflammatory cytokines, OxLDL, TNF-alpha, TGF-beta, and ANG II in vitro, and several proatherogenic factors in vivo. L2623-01A neutralizes LOX-1 and inhibits Hsp70 binding to dendritic cells and Hsp70-induced antigen cross-presentation. In vivo, targetting LOX-1 with a tumor antigen using anti-LOX-1 antibody induces antitumor immunity.
Catalog #L2623-01A
ApplicationsSuitable for use in Flow Cytometry, Immunofluorescence, Neutralization and functional studies. Other applications not tested.
Recommended DilutionFlow Cytometry: 1:50. 10ug/ml was used on human peripheral blood myeloid DC and macrophages.
Fuctional studies: totally prevents Hsp70 binding to LOX-1-CHO but not mock-transfected CHO cells (1).
Optimal dilutions to be determined by the researcher.
Positive ControlHuman APCs
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No9G219
HostMouse
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide. Labeled with Biotin.
PurityPurified by Protein G affinity chromatography.
ImmunogenFusion protein corresponding to the extracellular domain, aa71-273, of human LOX-1 with mouse Fcy1 (LOX-1-muFc) produced in PEAK cells.
SpecificityRecognizes human lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1). Species crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesSCARE1, CLEC8A, OLR2


External Links