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You are here:Home » Antibodies » Abs to Leukotrienes » Anti -Lipoxygenase, 5-, phosphorylated (Ser523) (5-LOX, 5-LO, 5-LPG, Arachidonate 5-Lipoxygenase, Arachidonic Acid 5-Lipoxygenase, ALOX5, Leukotriene A4 Synthase, LOG5, MGC163204)

Anti -Lipoxygenase, 5-, phosphorylated (Ser523) (5-LOX, 5-LO, 5-LPG, Arachidonate
5-Lipoxygenase, Arachidonic Acid 5-Lipoxygenase, ALOX5, Leukotriene A4 Synthase, LOG5,
MGC163204)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
The enzyme 5-lipoxygenase (5-LO) play a key role in regulating the production of leukotrienes (LTs) (Funk, 2001). Overproduction of LTs contribute to several diseases, most notably chronic inflammatory diseases, including asthma (Drazen et al., 1994) fibrosis (Wilborn et al., 1996) and atherosclerosis (Dwyer et al., 2004). Recent work has demonstrated that the activity of 5-LO is regulated by PKA phosphorylation of serine523 in 5-LO (Luo et al., 2004). Under normal conditions, this phosphorylation may be important in limiting inflammation. Abnormal signaling through cAMP and PKA could contribute to a variety of diseases, including those characterized by chronic inflammation. The phospho-specific antibody to ser523 on 5-LO is thus likely to provide a valuable tool for studies of the role of 5-LO regulation in diseases such as asthma, fibrosis, and atherosclerosis.
Catalog #L2623-10A
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
Form10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% glycerol
PurityPurified by immunoaffinity chromatography.
ImmunogenPhosphopeptide corresponding to amino acids residues surrounding the phospho Ser523 of human 5-Lipoxgenase (5-LO).
SpecificitySpecific for the ~80k 5-LO phosphorylated at Ser523 in Western blots of rat hippocampal lysate. Species Crossreactivity: Recognizes human and rat forms of 5-LO.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names5-Lipoxygenase


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