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You are here:Home » Antibodies » Abs to Leukotrienes » Anti -Lipoxygenase, 5-, phosphorylated (Ser523) (5-LOX, 5-LO, 5-LPG, Arachidonate 5-Lipoxygenase, Arachidonic Acid 5-Lipoxygenase, ALOX5, Leukotriene A4 Synthase, LOG5, MGC163204)

Anti -Lipoxygenase, 5-, phosphorylated (Ser523) (5-LOX, 5-LO, 5-LPG, Arachidonate
5-Lipoxygenase, Arachidonic Acid 5-Lipoxygenase, ALOX5, Leukotriene A4 Synthase, LOG5,
MGC163204)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
5-LO is an enzyme that catalyses the synthesis of leukotrienes (LT's) from arachidonic acid (a polyunsaturated fatty acid), by the insertion of an oxygen into the arachidonic backbone. 5-LO requires calcium, ATP and the 5-LO-activating protein as cofactors for full activity. Leukotrienes are synthesized and secreted by leukocytes in response to immunologic or inflammatory stimuli, such as in asthma and allergic reactions. The biological effects of LT's include leukocyte chemotaxis, pulmonary airway constriction, mucous hypersecretion, vasoconstriction and increased vascular permeability. I recent years 5-LO has also been implicated in the regulation of cell proliferation and apoptosis and has been found in a broad variety of cancer cells.
Catalog #L2623-10D
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 10mM HEPES, pH7.5, 150mM sodium chloride, 0.09% sodium azide, 0.01% BSA, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to an aa sequence within human 5-lipoxygenase which includes phosphorylated Ser523.
SpecificityRecognizes human 5-lipoxygenase when phosphorylated at Ser523 at ~80kD. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names5-Lipoxygenase


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