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You are here:Home » Antibodies » Abs to Enzymes, Oxidase » Anti -Lysyl Oxidase (LOX, Protein-lysine 6-oxidase)

Anti -Lysyl Oxidase (LOX, Protein-lysine 6-oxidase)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IP IH IF
Protein-lysine-6 oxidase; LOX (EC 1.4.3.13), a 30kD copper-containing amine oxidase, belongs to a heterogeneous family of enzymes that oxidize primary amine substrates to reactive aldehydes. It plays a vital role in the formation and repair of ECM. Localized both in the cytosol and nucleus, it catalyzes the oxidation and deamination of epsilon-NH2 group of lysine and hydroxylysine residues to alpha-aminoadipic-delta-semialdehyde. This is the first step that initiates the covalent cross-linking of collagen and tropoelastin resulting in the formation of insoluble collagen and elastic fibers in the extracellular matrix. LOX is a multifunctional enzyme having diverse biological functions such as developmental regulation, tumor suppression, cell motility and cellular senescence. Deficiency of LOX is seen in certain carcinomas and 3X-linked recessive human connective tissue disordersóCutis Laxa.
Catalog #L2623-11A
ApplicationsSuitable for use in Immunofluorescence/Immunocytochemistry, Western Blot, Immunohistochemistry and Immunoprecipitation. Other applications not tested.
Recommended DilutionsWestern Blot: 1:500
Immunohistochemistry (FFPE): 1:100
Immunohistochemistry: Frozen sections
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid, 0.025% sodium azide, 50% glycerol.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa305-320 DLLDANTQRRVAEGHK of human LOX. Species Sequence Homology: mouse, chimpanzee; 100%, rat, canine, porcine, bovine; 93%, Xenopus; 81%, chicken, 75%
SpecificityRecognizes human LOX.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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