Anti -LOX1 (LOX-1, hLOX-1, C-type Lectin Domain Family 8 Member A, CLEC8A, Lectin-like
Oxidized LDL Receptor 1, Lectin-like oxLDL Receptor 1, Lectin-type Oxidized LDL Receptor
1, LOXIN, Oxidized Low-density Lipoprotein Receptor 1, Ox-LDL Receptor 1, OLR1, SCARE
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
E IF |
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| LOX-1 is a receptor for oxidized low-density lipoproteins (LDL). This receptor mediates the recognition, internalization and degradation of oxidized LDL. It is a Type II membrane protein with a typical C-type lectin structure at the extracellular C-terminus which recognizes the ligand. LOX-1 activation by oxidized LDL causes endothelial changes such as decreased nitric oxide release and an increased expression of adhesion molecules. LOX-1 also binds activated platelets and apoptotic cells. The expression of LOX-1 is induced by pro-atherogenic conditions such as hyperlipidemia, hypertension and diabetes and as such appears to contribute to the pathogenesis of vascular disorders, particularly atherosclerosis. | | | Catalog # | L3514-54A | | Applications | Suitable for use in ELISA and Immunofluorescence. Other applications not tested. | | Recommended Dilutions | Immunofluorescence: 1:100-1:200. Fixation with 4% paraformaldehyde or methanol is recommended. | | Optimal dilutions to be determined by the researcher. | | Recommended Secondary Antibodies | I1903-30H: IgG, H&L, X-adsorbed (FITC) Pab Sh xRb | | I1903-30T: IgG, H&L, X-adsorbed (Biotin) Pab Sh xRb | | I1903-30U: IgG, H&L, X-adsorbed (HRP) Pab Sh xRb | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | Not Determined | | Form | Supplied as a liquid, 0.09% sodium azide. | | Purity | Serum | | Immunogen | Peptide corresponding to the C-terminal (extracellular) region of human LOX-1. | | Specificity | Recognizes the extracellular domain of human LOX-1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Oxidized Low Density Lipoprotein (Lectin-like) Receptor 1 |
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Download Specifications for Anti -LOX1 (LOX-1, hLOX-1, C-type Lectin Domain Family 8 Member A, CLEC8A, Lectin-like Oxidized LDL Receptor 1, Lectin-like oxLDL Receptor 1, Lectin-type Oxidized LDL Receptor 1, LOXIN, Oxidized Low-density Lipoprotein Receptor 1, Ox-LDL Receptor 1, OLR1, SCARE |
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