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You are here:Home » Antibodies » Abs to Leukotrienes » Anti -LOX1 (LOX-1, hLOX-1, C-type Lectin Domain Family 8 Member A, CLEC8A, Lectin-like Oxidized LDL Receptor 1, Lectin-like oxLDL Receptor 1, Lectin-type Oxidized LDL Receptor 1, LOXIN, Oxidized Low-density Lipoprotein Receptor 1, Ox-LDL Receptor 1, OLR1, SCARE

Anti -LOX1 (LOX-1, hLOX-1, C-type Lectin Domain Family 8 Member A, CLEC8A, Lectin-like
Oxidized LDL Receptor 1, Lectin-like oxLDL Receptor 1, Lectin-type Oxidized LDL Receptor
1, LOXIN, Oxidized Low-density Lipoprotein Receptor 1, Ox-LDL Receptor 1, OLR1, SCARE

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E IF
LOX-1 is a receptor for oxidized low-density lipoproteins (LDL). This receptor mediates the recognition, internalization and degradation of oxidized LDL. It is a Type II membrane protein with a typical C-type lectin structure at the extracellular C-terminus which recognizes the ligand. LOX-1 activation by oxidized LDL causes endothelial changes such as decreased nitric oxide release and an increased expression of adhesion molecules. LOX-1 also binds activated platelets and apoptotic cells. The expression of LOX-1 is induced by pro-atherogenic conditions such as hyperlipidemia, hypertension and diabetes and as such appears to contribute to the pathogenesis of vascular disorders, particularly atherosclerosis.
Catalog #L3514-54A
ApplicationsSuitable for use in ELISA and Immunofluorescence. Other applications not tested.
Recommended DilutionsImmunofluorescence: 1:100-1:200. Fixation with 4% paraformaldehyde or methanol is recommended.
Optimal dilutions to be determined by the researcher.
Recommended Secondary AntibodiesI1903-30H: IgG, H&L, X-adsorbed (FITC) Pab Sh xRb
I1903-30T: IgG, H&L, X-adsorbed (Biotin) Pab Sh xRb
I1903-30U: IgG, H&L, X-adsorbed (HRP) Pab Sh xRb
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid, 0.09% sodium azide.
PuritySerum
ImmunogenPeptide corresponding to the C-terminal (extracellular) region of human LOX-1.
SpecificityRecognizes the extracellular domain of human LOX-1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesOxidized Low Density Lipoprotein (Lectin-like) Receptor 1


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